Unconjugated Estradiol (UE3) is a routine second-trimester laboratory test used to measure the levels of unconjugated estriol in the blood of pregnant women. Congenital abnormalities and chromosomal variations in newborns are diagnosed by testing the estriol levels. Estriol is produced by the placenta (a protective covering for the foetus) from maternal substrates (cholesterol and pregnenolone). Estriol diffuses from the placenta into the maternal blood, where it can be measured as unconjugated uE3. In normal pregnancies, uE3 levels increase from about 4 nmol/L at 15 weeks gestation to about 40 nmol/L at delivery. The test is mainly used to diagnose Down syndrome when the levels are lower than the standard threshold, which is 14.60 ng/ml in pregnant women. An abnormally low UE3 level can also indicate the possibility of aromatase deficiency, congenital adrenal hyperplasia, primary or secondary (including maternal corticosteroid therapy) foetal adrenal insufficiency and/or foetal demise. The reasons for undergoing the Unconjugated Estradiol (UE3) test include:The panel is used to monitor the baby's health in the mother's womb.It is a routine second-trimester test performed on the mother's blood to determine the pregnancy progress.Pregnancy risk monitoring: If your healthcare professional feels that the pregnancy is at risk, they may request this test serially over many days to track changes in E3 levels.The E3 test is part of the triple marker test, which also analyses AFP and hCG levels in the mother's blood. It's a test to see if the baby has any genetic abnormalities. The Unconjugated Estradiol (UE3) test requires a blood sample for analysis. A healthcare professional will collect a small amount of blood from a vein, typically from the arm. The area is first cleaned with an antiseptic, and then a needle is inserted to draw the blood into a vial or syringe. The procedure is relatively quick and safe, with minimal discomfort. Once the blood sample is collected, it is sent to the laboratory for analysis. The sample is processed to extract the unconjugated estriol, which is then measured using specialised equipment. The results are usually available within 48 hours. It is important to note that the test results should be interpreted by a healthcare provider who can assess the individual's specific medical history and symptoms. If the Unconjugated Estradiol (UE3) test reveals abnormal levels of unconjugated estriol, further evaluation may be recommended to determine the health of the foetus in the mother's womb. So, it is essential to consult with a healthcare professional who can provide personalised guidance and develop an appropriate treatment plan. If you are looking for an effective and reliable Unconjugated Estradiol (UE3) test, look no further than Apollo 24|7. The reasons why you should consider getting the test done early are as follows: 1. Accurate Assessment: Early testing allows for the timely identification of any potential foetal abnormality, enabling prompt intervention and management. 2. Pregnancy risk monitoring: The healthcare professional may request this test to determine the risks to the pregnancy. 3. Prenatal diagnostic tests: provide information on the foetus's health, which can help families and healthcare providers make decisions about the pregnancy or the foetus To book the Unconjugated Estradiol (UE3) test, you can visit the Apollo 24|7 website or app and select the desired test. The process is simple and convenient, allowing you to choose a suitable date and convenient time slot for sample collection at one of the Apollo 24|7 diagnostic centres. Reports are typically available within 48 hours, ensuring timely access to accurate results.